52 results
Signs of Graves disease: 
• Goiter 
• Periorbital edema 
• Non-pitting edema causing hyperpigmented plaques 
•
Signs of Graves ... disease: • Goiter ... ) #Graves #disease ... #Signs #Clinical ... #Photo #Diagnosis
Dermatomyositis
A middle-aged man describes progressive difficulty combing his hair and rising from a seated position over
Dermatomyositis ... This is a case of dermatomyositis ... rash, 2) shawl sign ... Gottrons #Papules #Clinical ... #Photo
The diagonal crease in the lobe of the ear (Frank's sign) is a sign theoretically related
coronary artery disease ... groove and coronary disease ... could be useful in clinical ... #Earlobe #Clinical ... #Photo
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease ... Pathophsiology ... in GBA1 gene Clinical ... #Gauchers #Disease ... #Diagnosis #Signs
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... auricular papules Clinical ... severity of the disease
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... Pathogenesis and clinical ... flexors affected #Dermatomyositis ... PM #Diagnosis #Pathophysiology ... #Signs #Symptoms
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Graves’ Disease: ... Pathogenesis and Clinical ... the etiology Signs ... GravesDisease #pathophysiology ... endocrinology #symptoms #signs
Shawl sign poikiloderma in Dermatomyositis

Poikiloderma in general is a common finding in older individuals with chronic
Shawl sign poikiloderma ... along with other signs ... RashDecisionz #Shawl #sign ... #Dermatology #Clinical ... #Photo #Neck
Terry's Nails

Proximal paleness extending halfway up the nail, often eliminating the lunula. Darker distal band. Seen
advanced age, liver disease ... #PhysicalExam #Clinical ... #Photo #Sign
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
Pathogenesis and Clinical ... Environmental triggers ... PolyarteritisNodosa #Pathophysiology ... #Diagnosis #Signs