10 results
Gastroesophageal Reflux Disease (GERD) - Summary

GERD: Diagnosis
• Heartburn (substernal burning sensation) and acid regurgitation
• Chest pain
Extraesophageal
sensation) and acid ... and pulmonary symptoms ... failure or alarm symptoms ... reduction • Avoid “trigger ... Disease #diagnosis #management
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... fraction • HTN #GrowthHormone ... diagnosis #signs #symptoms ... #endocrinology ... #pathophysiology
GERD and Recommended Lifestyle Modifications
 • Avoid fatty meals
 • Avoid carbonated beverages
 • Avoid citrus,
GERD and Recommended ... citrus, if it triggers ... symptoms • Eat ... #reflux #acid # ... Modifications #management
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... hyperviscosity syndrome • Triggers ... into serum • Triggers ... Elevated uric acid ... TLS #diagnosis #management
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... fetal free fatty acid ... Intermediate fatty acid ... postpartum): • Initial symptoms ... #pathophysiology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
the study) • Triggers ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... APML #diagnosis #management
Esophageal Necrosis
Etiology:
 - Ischemia and Gastric Outlet Obstruction with GERD may be inciting events
 - Associated
Obstruction with GERD ... topical injury (by acid ... melena - Other GI symptoms ... Necrosis #diagnosis #management
Cryptogenic Organizing Pneumonia - Illness Script

PATHOPHYSIOLOGY: Unknown trigger, reversible inflammatory/fibroproliferative process. Polypoid fibroblastic aggregates that plug
Illness Script PATHOPHYSIOLOGY ... : Unknown trigger ... Females SIGNS/SYMPTOMS ... misdiagnosed as CAP • Symptoms ... Pneumonia #diagnosis #management
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
disorders, including acid ... cell lymphoma Pathophysiology ... and the systemic symptoms ... TAFRO #diagnosis #management