58 results
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... metabolic abn #GrowthHormone ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... fraction • HTN #GrowthHormone ... diagnosis #signs #symptoms ... #endocrinology ... #pathophysiology
Primary vs Secondary Adrenal Insufficiency - Pathophysiology
Primary AI = adrenal glands themselves are the problem. This
Insufficiency - Pathophysiology ... pituitary gland is ... their RAA axis is ... Insufficiency #Pathophysiology ... #endocrinology
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Androgens: • Symptoms ... physical: - Symptoms ... - ACTH test is ... - ACTH test is ... addisons #disease #endocrinology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... hyperviscosity syndrome • Triggers ... Lysis Syndrome: • Pathophysiology ... into serum • Triggers ... TLS #diagnosis #management
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
environmental triggers ... expression - Age: GCA is ... old; F>M Signs/Symptoms ... Temporal #Arteritis #Pathophysiology ... Diagnosis #Signs #Symptoms
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Symporter) but is ... etiology Signs/Symptoms ... GravesDisease #pathophysiology ... #endocin #endocrinology ... #symptoms #signs
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
Predisposition: patient is ... Environmental triggers ... Hypertension - Renal ... PolyarteritisNodosa #Pathophysiology ... Diagnosis #Signs #Symptoms
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
of hCG, which is ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Adrenal Insufficiency - Diagnosis and Management Summary
Primary Adrenal Insufficiency:
Most Common Cause in the US: Autoimmune Adrenalitis
Other
Adrenal Insufficiency ... Diagnosis and Management ... ketoconazole, etomidate) Symptoms ... Secondary #Diagnosis #Management ... #Endocrinology