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management anemia differential cll lymphocytic mds myelodysplastic treatment algorithm calculation causes chemistry diffuse hemeonc index lad lfts liver lymphadenopathy myelodysplasia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... • Bone marrow ... transformation to acute leukemia ... Management #treatment #hematology ... #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... with hypocellular bone ... to MDS or acute leukemia ... #Anemia #diagnosis ... management #treatment #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
- Differential Diagnosis ... Age > 50 • Chronic ... #Differential #Diagnosis ... Algorithm #Causes #Hematology ... #Oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... with a relatively chronic ... involvement CML (Chronic ... #Hematology #Oncology ... #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
= Hypocellular bone ... virus (EBV) • Leukemia ... • Suggested by bone ... #Anemia #oncology ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Pure red cell aplasia ... Warm AIHA • Bone ... #CLL #Chronic ... #oncology #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
• Anemia of chronic ... Hypogonadism • Bone ... marrow failure: Aplastic ... Production #Index #hematology ... #differential #diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... minimal tumor burden Diagnosis ... uw_IMresidency #CLL #Chronic ... #oncology #hematology ... #hemeonc #diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Chemistries - Interpretation ... > 2 • NASH, Chronic ... hemolysis) • ALP: Bone ... liver #chemistry #diagnosis ... #differential #Hepatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Causes • Anemia • Aplastic ... Marrow Failure • Chronic ... Myelogenous Leukemia ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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