76 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
• softening of bones ... of feet, thigh bones ... neuropathy • Renal ... : - Renal failure ... Hyophosphatasia #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
for the liver ALP ... abnormality vs bone ... Transaminase, ALP ... / ULN ALT) / (ALP ... Transaminitis #diagnosis #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
stimulation (placenta/Bone ... - Highest • Bone ... Pregnancy - Renal ... disease - Bone ... Diagnosis #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Cholestasis • ALP ... disease • If ALP ... • Elevation of ALP ... : Bone, First trimester ... #differential #Hepatology
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary
Clinical features - Classic triad (flank pain, hematuria,
Renal Cell Carcinoma ... Bone scan is indicated ... patients with bone ... pain and ↑ ALP ... , and/or ALP 5.
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
specificity to elevated ALP ... GGT/5-NT: ↑ - ALP ... hemolysis) • ALP ... : Bone, first trimester ... diagnosis #algorithm #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Chemistry Tests - AST, ALT ... Metabolism AST and ALT ... Other locations: bone ... clearance - AP ... AlkPhos #Bilirubin #Hepatology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Boxes in yellow ... box indicates all ... ALP, alkaline phosphatase ... ; ALT, alanine aminotransferase ... Abnormal #Algorithm #Hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
aminotransferase (ALT ... ) - Liver, bone, ... brain, NOT in bone ... pancreas, NOT in bone ... Interpretation #diagnosis #hepatology
Indications for Serum Protein Electrophoresis (SPEP)
 • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
associated with renal ... insufficiency and bone ... loss, fatigue, bone ... blood smear • Renal ... Electrophoresis #SPEP #Hematology