62 results
Bone Lesion on X-Ray - Differential Diagnosis Algorithm 
Exostotic
 • Osteochondroma
Asymptomatic &/or Non-Active Bone Scam
 •
Bone Lesion on X-Ray ... Differential Diagnosis Algorithm ... /or Non-Active Bone ... • Unicameral Bone ... Constitutional Symptoms
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
mechanical loading => Bone ... strain => Bone ... #orthopedics #pathophysiology ... #symptoms #signs
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... #Osteoporosis #pathophysiology ... #signs #symptoms
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Phosphate Physical Symptoms ... signs, Fragile bones ... easily/weakness, Bone ... pain Psychiatric Symptoms ... Secondary #Tertiary #pathophysiology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... stimulation (placenta/Bone ... - Highest • Bone ... Renal disease - Bone ... symptoms - Pain
Hypercalcemia of Malignancy - Pathophysiology
PTH-mediated
 • Parathyroid cancer
 • Ectopic production: Small cell lung cancer, ovarian
of Malignancy - Pathophysiology ... resorption in the bone ... resorption in the bone ... Hypercalcemia #Malignancy #Pathophysiology ... Differential #Diagnosis #algorithm
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
in subchondral bone ... architecture -> Palpable bony ... contact between bony ... Osteoarthritis #OA #pathophysiology ... diagnosis #signs #symptoms
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
3: Necrosis of bone ... mass over mastoid bone ... of the temporal bone ... inner cortical bone ... #signs #symptoms
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Clinical Signs/Symptoms ... back pain - Symptoms ... decreased reflexes Pathophysiology ... of bacilli to bone ... CXR should be done
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Sporadic mutation -> One ... gene mutated in one ... Inherited mutation -> One ... Retinoblastoma #pathophysiology ... diagnosis #signs #symptoms