16 results
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Pathogenesis and clinical ... mechanical loading => Bone ... strain => Bone ... StressFractures #msk ... #orthopedics #pathophysiology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... • recurrent fractures ... collection with EDTA Pathophysiology ... pain - Frequent fractures ... Hyophosphatasia #hepatology
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
Pathogenesis and clinical ... Bisphosphonate suppresses bone ... damage weakens the bone ... #msk #orthopedics ... differential #causes #pathophysiology
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
: Mechanisms, Clinical ... Direct/indirect AP ... Grade 2 - Rami fracture ... #Orthopedics #MSK ... complications #pathophysiology
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... Pathogenesis and clinical ... tear a portion of bone ... #msk #diagnosis ... #pathophysiology
Spondylolysis & Spondylolisthesis: Pathogenesis and Clinical Findings

Pars interarticularis stress fracture (spondylolysis) - most frequently in the
Pathogenesis and Clinical ... interarticularis stress fracture ... vertebrae • CT - collar ... Spondylolisthesis #MSK ... #diagnosis #pathophysiology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
prognosis • Nodular ... lymphocyte predominant (LP ... Amy Chung, MD, MSc ... Classification #pathophysiology ... #Hematology #Diagnosis
Paget’s Disease: Pathogenesis and Clinical Findings

 • Incr serum CTx - marker of bone resorption
 •
Pathogenesis and Clinical ... CTx - marker of bone ... , kyphosis and fractures ... • Incr serum ALP ... PagetsDisease #pathophysiology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Mucous membranes • Bone ... poor nutrition Clinical ... mucocutaneous changes, ocular ... • Delusions Ocular ... nonimmune hemolysis MSK
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
fever syndromes Clinical ... Fever is the main clinical ... tests ↑ AST ↑ ALT ... Histopathologic features ... Diagnosis #Management #Hematology