62 results
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... liver or kidney disease ... #Osteoporosis #pathophysiology ... #signs #symptoms
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
in Sickle Cell Disease ... other orthopedic complications ... • Differentiate ... Pain #SickleCell #Disease ... #differential #
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... - Highest • Bone ... Most common symptoms ... - Bone symptoms ... ALP #Elevation #Differential
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Musculoskeletal #Complications ... #pathophysiology ... #signs #symptoms
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease ... Pathophsiology ... Osteonecrosis, bone ... #Gauchers #Disease ... Diagnosis #Signs #Symptoms
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
tear a portion of bone ... lateral hip Signs/Symptoms ... /Complications: ... msk #diagnosis #pathophysiology ... #signs #symptoms
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
in subchondral bone ... Osteoarthritis #OA #pathophysiology ... diagnosis #signs #symptoms ... #complications
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome Signs/Symptoms ... /Complications: ... Infertility • Decr Bone ... Syndrome #genetics #pathophysiology
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer’s Disease ... chromosome 21) Signs / Symptoms ... / Complications ... AlzheimersDisease #Dementia #pathophysiology ... diagnosis #signs #symptoms
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
paresthetica • Symptoms ... 3-6 months of symptom ... intervertebral disc disease ... MeralgiaParesthetica #MSK #pathophysiology ... #differential #