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management differential hematology msk oncology orthopedics syndrome clinical hepatology neurology pathophysiology summary signs dermatology rheumatology alkaline alp cardiology chronic classification
Paget's Disease of Bone • Characterized by an ↑ rate of bone turnover with both excessive
by an ↑ rate of bone ... and formation of bone ... • Caused by ( ... #Bone #diagnosis ... #management #treatment
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Algorithm ALP ... stimulation (placenta/Bone ... - Highest • Bone ... Intestine - Other causes ... - Bone symptoms
Bone Lesion on X-Ray - Differential Diagnosis Algorithm Exostotic • Osteochondroma Asymptomatic &/or Non-Active Bone Scam •
Bone Lesion on X-Ray ... /or Non-Active Bone ... • Unicameral Bone ... Constitutional Symptoms ... #Causes
Causes of Dizziness - Vertigo - Differential Diagnosis Algorithm True Vertigo - Illusion of Rotary Movement Peripheral Vestibular
Causes of Dizziness ... Algorithm True ... • Meniere's Disease ... Media • Temporal Bone ... #Algorithm #Causes
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
- Differential Diagnosis ... Algorithm Elevated ... Granulomatous Disease ... Miscellaneous - Bone ... #Algorithm #causes
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm Tumours - See Bone Lesions Scheme Paget's Disease -
- Differential Diagnosis ... Algorithm Tumours ... - See Bone Lesions ... • Bone Marrow ... #Causes
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver, bone ... Most cases diagnosed ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: ... excessive bone ... turnover -> Incr bone ... pathophysiology #diagnosis ... #signs #symptoms
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... • Bone and joint ... Rule out other causes ... and lower jaw Treatment ... osteoarticular and skin disease
Vascular Joint Pain - Differential Diagnosis Algorithm - Constant Pain (Ischemia) - Acute Onset -
Algorithm - ... Peripheral Vascular Disease ... fractured long bone ... • Dislocated Bone ... #Causes
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