12 results
Aplastic Anemia and Bone Marrow Failure Syndromes with Pancytopenia

Fanconi Anemia
Acquired Aplastic Anemia
Dyskeratosis Congenita & Telemore Biology
Aplastic Anemia ... and Bone Marrow ... Syndromes with Pancytopenia ... lauraebrown #Pancytopenia ... anemia #diagnosis #Hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... Diagnosis: • Pancytopenia ... with hypocellular bone ... to MDS or acute leukemia ... management #treatment #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Pancytopenia - Workup ... Flow cytometry, Bone ... Alcoholism Bone ... FISH • Acquired Aplastic ... Diagnosis #Algorithm #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
marrow + pancytopenia ... Headaches • Pale skin ... virus (EBV) • Leukemia ... #Anemia #oncology ... #hematology #diagnosis
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Neoplastic: - Leukemia ... Lymphoblastic Leukemia ... (Pancytopenia, ... Algorithm #Causes #Hematology ... #Oncology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Pancytopenia - Workup ... Flow cytometry, Bone ... Alcoholism Bone ... FISH • Acquired Aplastic ... Diagnosis #Algorithm #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... • Bone marrow ... transformation to acute leukemia ... Management #treatment #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... Pure red cell aplasia ... Warm AIHA • Bone ... diagnosis #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... cells - Blood and Bone ... • Headaches, bone ... CLL -> Invade Skin ... #Hematology #Oncology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... Causes • Anemia • Aplastic ... • Hairy Cell Leukemia ... Syndromes #diagnosis #hematology ... #oncology