58 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... • softening of bones ... of feet, thigh bones ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
fractures in elderly Causes ... Bisphosphonate suppresses bone ... damage weakens the bone ... #differential #causes ... #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Myopathy (Also caused ... Complications #pathophysiology
Fat Embolism Syndrome
Trauma to the long bone or pelvis accounts for —9096 of cases. The diagnosis
Trauma to the long bone ... accounts for —9096 of cases ... Pathophysiology
Bilateral B-Lines in case of Pneumonia on Lung POCUS

Young healthy pt with fever/dyspnea. POCUS lung exam
Bilateral B-Lines in case ... Pneumonia on Lung POCUS ... POCUS lung exam ... Lung POCUS shows ... Robert Jones @RJonesSonoEM
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Abnormal Osteoclasts cause ... excessive bone ... Skull expansion causes ... causes middle ear ... PagetsDisease #pathophysiology
Constrictive Pericarditis on POCUS Echocardiogram - Apical 3-Chamber View

Young Lupus patient admitted to hospital new onset
Pericarditis on POCUS ... could pinpoint the cause ... New onset HFpEF case ... Robert Jones @RJonesSonoEM ... Pericarditis #CP #POCUS
Pneumoperitoneum from perforated duodenal ulcer on RUQ POCUS

Male with severe RUQ abdominal pain. Answer in thread.
duodenal ulcer on RUQ POCUS ... as shown in the case ... worry about rare case ... Robert Jones @RJonesSonoEM ... duodenal #ulcer #RUQ #POCUS
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... , Biological + Bone ... /ml, ↑ LDH • Bone ... Drugs, Unknown cause ... 100 mg/m2) : in case
Constrictive Pericarditis on POCUS Echocardiogram - Subcostal View

Young Lupus patient admitted to hospital new onset HFpEF.
Pericarditis on POCUS ... could pinpoint the cause ... New onset HFpEF case ... Robert Jones @RJonesSonoEM ... Pericarditis #CP #POCUS