9 results
diagnosis peds endocrinology ossification signs wrist 21hydroxylasedeficiency 21ohd agammaglobulinemia age complications feedbackloop gh growthhormone hematology hemeonc hemophagocytic hlh immunology lymphohistiocytosis
Ossification of Carpal Bones It’s always tricky to remember the age of ossification of the carpal bones
Ossification of Carpal ... ossification of the carpal ... interpreting a Pediatric ... -6-7 years for Triquetral ... Diagnosis #Peds #Pediatrics
Age of Ossification of Carpal Bones Capitate - 1 Month Hamate - 2 Months Triquetral - 3 Years Lunate -
Ossification of Carpal ... Bones Capitate ... Hamate - 2 Months Triquetral ... bones! ... diagnosis #msk #pediatrics
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome Signs/Symptoms ... Infertility • Decr Bone ... PraderWilli #Syndrome #genetics ... #pathophysiology ... #peds #pediatrics
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... lipolysis Signs/Symptoms ... expansion (e.g. carpal ... endocrinology #pathophysiology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology ... #peds #pediatrics
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
in subchondral bone ... boggy" joints, esp carpal ... and subcondral bone ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
Genetic Predisposition ... immunity Signs/Symptoms ... cells in blood and bone ... Agammaglobulinemia #XLinked #pathophysiology
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
cause excessive bone ... turnover -> Incr bone ... the vertebral canal ... PagetsDisease #pathophysiology ... diagnosis #signs #symptoms
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Familial) HLH: - Genetic ... Common Signs and Symptoms ... Pathophysiology ... Hemophagocytosis in bone
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