15 results
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Signs/Symptoms ... Infertility • Decr Bone ... mineral density and osteoporosis ... #genetics #pathophysiology ... #peds #pediatrics
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
Osteoporosis: Pathogenesis ... 30 (post-peak bone ... Decr estrogen • Bone ... #pathophysiology ... #signs #symptoms
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
signs, Fragile bones ... /osteoporosis, Kidney ... easily/weakness, Bone ... pain Psychiatric Symptoms ... Secondary #Tertiary #pathophysiology
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Glucocorticoid-Induced Osteoporosis ... -> Reduced Bone ... Formation, Increased Bone ... #pathophysiology ... #signs #symptoms
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease Pathophsiology ... Osteonecrosis, bone ... infarcts, osteoporosis ... Diagnosis #Signs #Symptoms
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Normal CK • Osteoporosis ... Complications #pathophysiology ... #signs #symptoms
Short Bowel Syndrome - Acute and Chronic Adverse Signs and Symptoms of Ileal Resection
 • Dehydration
Short Bowel Syndrome ... Nephropathy • Bone ... Disease, Osteoporosis ... #Signs #Symptoms ... Ileal #Resection #pathophysiology
Fat Embolism Syndrome
Trauma to the long bone or pelvis accounts for —9096 of cases. The diagnosis
Fat Embolism Syndrome ... Trauma to the long bone ... Pathophysiology ... Fat #Embolism #Syndrome ... Diagnosis #Signs #Symptoms
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
mutations - Down syndrome ... chromosome 21) Signs / Symptoms ... AlzheimersDisease #Dementia #pathophysiology ... #geriatrics #diagnosis ... #signs #symptoms
Acquired Disorders of Reduced Bone Strength: Pathogenesis
 • Hyperparathyroidism
 • Vitamin D deficiency
 • Malabsorption syndromes
Disorders of Reduced Bone ... Malabsorption syndromes ... Other causes of bone ... #BoneStrength #pathophysiology ... differential #diagnosis #osteoporosis