18 results
diagnosis hematology anemia algorithm causes classification hepatitis liver management mcv aflp agglutinin aiha autoimmune calculation cold common cvid dermatology diseases
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Microangiopathic hemolytic ... purpura (TTP), Hemolytic ... Extravascular #Causes #differential
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Diagnosis Table ... Cold Agglutinin Disease ... #Autoimmune #Hemolytic ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... inclusions - If infection ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... younger pts) Differential ... intravascular hemolysis ... #hemolytic #anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
-100): • Non-hemolytic ... anemia, CKD • Hemolytic ... Macroangiopathic, Infections ... Non-megaloblastic: Liver disease ... #Diagnosis #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Internal (RBC) - Infections ... Urobilinogen #Hemolysis ... #Differential # ... Diagnosis #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Congenital Diseases ... Antibody-mediated hemolysis ... deficiency Infections ... #Diagnosis #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Splenomegaly - Differential ... Diagnosis Algorithm Infectious ... Serum Sickness Hemolytic ... Spleen #Enlarged #Differential ... Algorithm #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Causes: • Liver disease ... drug induced • Infections ... udaygulati #Hemolytic
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Chronic kidney disease ... (e.g. cancer, infection ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... #anemia #differential
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