14 results
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Idiopathic • Infections ... - HIV • Immune ... and thymoma DDX ... Anemia #oncology #hematology ... #diagnosis #management
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Thrombocytopenia - Differential ... Megakaryopoiesis • Aplastic ... Quinidine • HIT ... Vasculitis • Infection ... Algorithm #Causes #Hematology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
and M panel Management ... DDX - Other causes ... Epstein-Barr syndrome, HIV ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
fraction < 20% Differential ... Diaqnoses: • Infectious ... Coxsackie, CMV, EBV, HIV ... Disease #diagnosis #management ... #treatment #rheumatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Diagnosis and Management ... skin necrosis (at injection ... Management: • ... re-challenge >100d after Dx ... #Treatment #Hematology
Approach to Elevated Tryptase - Differential Diagnosis Framework

The DDx of elevated tryptase can be broken down
Elevated Tryptase - Differential ... Framework The DDx ... NSAIDs/Aspirin, IV ... • Parasitic infections ... #Diagnosis #hematology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia 

DIAGNOSTIC CRITERIA FOR ICL
 • Persistent CD4 T-cell lymphopenia
 •
Heme (lymphoma. aplasia ... myelodysplasia) • Infections ... - HIV. ... ICL #diagnosis #hematology ... #Differential #
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
initiation • Differential ... Diagnosis: Infection ... • Steroids: IV ... APML #diagnosis #management ... #hematology #oncology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
due to marrow aplasia ... Infection - Infection ... Extremely rare - HIV ... Transfusion #diagnosis #management ... #hematology #reactions
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitides - Differential ... to exclude are infections ... CTD) • ANCA (Dx ... Cryoglobulins • HIV ... #diagnosis #rheumatology