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diagnosis differential hematology anemia management algorithm blood extravascular fever hemolysis infectiousdiseases product reactions american bruising cdc classification hemophagocytic hlh intermittent
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... spherocytosis) • Infections ... : Malaria, Babesiosis ... #Hemolytic #Intravascular ... #Causes #differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... and Intravascular ... circulation - Infections ... • Malaria ... Diagnosis #Algorithm #Causes
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... drug induced • Infections ... Bartonella, Babesia, Malaria ... IVIG infusion Intravascular ... udaygulati #Hemolytic
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Immune mediated hemolysis ... Fevers, DAT (-) → Infection ... Malaria, Clostridium ... Diagnosis #Algorithm #causes
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
bacteremia • Malaria ... endocarditis, malaria ... Causes: • Still's ... with profound hemolysis ... ) • Malaria
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Triggering factor (infection ... Leishmaniosis, malaria ... lymphoma (DLBCL, intravascular ... Still disease, Infection ... Drugs, Unknown cause
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... Infection - Infection ... infections with ... tested include: Malaria ... Lyme disease), Trypanosoma
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... • Infection - ... Infection occurs ... tested include: Malaria ... Lyme disease), Trypanosoma
Trypanosomiasis - Trypanosoma cruzi Life Cycle 1) Triatomine bug takes a blood meal (passes metacyclic trypomastigotes in
Trypanosomiasis - Trypanosoma ... a blood meal (passes ... amastigotes in new infection ... TrypanosomaCruzi #Tcruzi #LifeCycle
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
, a common cause ... No hemolytic anemia ... of malaria diagnosed ... • Falciparum malaria ... diagnostic tests for malaria
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