36 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... : → Massive tumor ... TumorLysis #syndrome #TLS ... #Pathophysiology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... TumorLysis #Syndrome #TLS ... #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor ... /- rasburicase Tumor ... : Lysis of tumor ... rate or large tumor ... #Leukostasis #Tumor
Acute and Chronic Causes of Dyspnea - Differential Diagnosis
Pulmonary/Chest Wall:
 • Acute: Trauma, COPD exacerbation, Asthma
Differential Diagnosis Pulmonary ... ILD, Sarcoid, Tumor ... Pleural effusion, Pulmonary ... : Tumor, Vocal cord ... : ALS, Glycogen
Causes of Peripheral Weakness with Sensory Changes - Differential Diagnosis Algorithm
Radiculopathy:
 • Disc
 • Spondylosis
 •
Spondylosis • Tumor ... • Trauma • Tumor ... • Diabetes • Tumor ... Spondylysis • Chronic ... Weakness #Sensory #Neurology
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... worsens above #Tumor ... Lysis #Syndrome #TLS ... #Pathophysiology
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Myelitis, Trauma, Tumor ... Motor Nerves: ALS ... Mononeuritis multiplex, Phrenic ... differential #diagnosis #neurology
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
: UMN (stroke, tumor ... Polyneuropathy, ALS ... Diagnosis #causes #neurology
Causes of Seizures - Differential Diagnosis Algorithm
Unprovoked - Epilepsy:
 • Focal: Simple, Complex
 • Generalized: Absence,
Myoclonic, Tonic, Clonic ... Atonic, Tonic-clonic ... • Structural: Tumor ... Algorithm #Causes #neurology