26 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... : → Massive tumor ... #TumorLysis #syndrome ... #TLS #Pathophysiology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... #TumorLysis #Syndrome ... #TLS #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor ... /- rasburicase Tumor ... : Lysis of tumor ... rate or large tumor ... #Leukostasis #Tumor
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
allele of RB1 tumor ... allele of RB1 tumor ... / Symptoms / Complications ... Retinoblastoma #pathophysiology ... #ophthalmology
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... worsens above #Tumor ... #Lysis #Syndrome ... #TLS #Pathophysiology
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Isocoria - Pupillary Defects - Differential Diagnosis Algorithm
Relative Afferent Pupil Defect
 • Optic Neuritis
 • Ischemic
Pupillary Defects - Differential ... • Optic Nerve Tumor ... Midbrain (Parinaud's Syndrome ... ): • Tumor • ... Algorithm #Causes #Ophthalmology
Keratoconus: Pathogenesis and Clinical Findings
Genetics
 • Family history of keratoconus
 • Ehlers-Danlos syndrome
 • Down, Turner,
• Down, Turner ... , Marfan syndromes ... / Symptoms / Complications ... #Keratoconus #pathophysiology ... #ophthalmology
Important Causes of Diplopia 
TIER 1-CRITICAL
Basilar artery thrombosis, Botulism, Basilar meningitis, Aneurysmn
TIER 2-EMERGENT:
Vertebral dissection, Myasthenia gravis,
, Orbital apex syndrome ... URGENT: Brainstem tumor ... Miller-Fisher syndrome ... mass #Diplopia #differential ... #diagnosis #ophthalmology
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
• Pituitary turnors ... the pituitary tumor ... Signs / Symptoms ... / Complications ... mnemonic #GLFTAP #pathophysiology