34 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... : → Massive tumor ... TumorLysis #syndrome #TLS ... #Pathophysiology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... TumorLysis #Syndrome #TLS ... #Pathophysiology
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... worsens above #Tumor ... #Pathophysiology ... #oncology
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor ... Lysis Syndrome (TLS ... Laboratory TLS ... Calcium ≤ 7.0 mg/dL Clinical ... diagnosis #management #oncology
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... Treatment of Clinical ... ICU transfer • Tumor ... #Tumor #Lysis # ... diagnosis #management #oncology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor ... /- rasburicase Tumor ... : Lysis of tumor ... rate or large tumor ... #Leukostasis #Tumor
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Tumor markers in clinical practice
Colorectal - CEA
Hepatocellular - AFP
Pancreatic - CA 19-9
Ovarian - CA 125
Breast -
Tumor markers in ... clinical practice ... thyroglobulin #Tumor ... laboratory #diagnosis #oncology
Risk factor for VTE in cancer patients

Tumor type 

• Very high risk: gastric, pancreas, brain 

•
cancer patients Tumor ... High risk: lung, hematologic ... #VTE #cancer #oncology
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... wandering_er #Tumor ... Lysis #Syndrome #TLS ... #oncology #management