20 results
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... Corticosteroid use • Primary ... #Osteoporosis #pathophysiology ... #signs #symptoms
Diagram of different types of bone tumors that can occur around the knee on XRay -
Diagram of different types ... of bone tumors ... ) • Enostosis/bone ... docskalski #Knee #Bone ... Tumors #Diagnosis #Bony
Diagram of different types of bone tumors that can occur around the knee on XRay
Age <
Diagram of different types ... of bone tumors ... blade of grass sign ... #Differential # ... Radiology #XRay #MSK
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm 
Tumours
 - See Bone Lesions Scheme
Paget's Disease
 -
Tumours - See Bone ... Phosphate Deficiency Primary ... • Bone Marrow ... Malignancy • Drugs (e.g ... Fractures #Pathologic #MSK
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Pathophsiology ... Neurological involvement (type ... Osteonecrosis, bone ... #Diagnosis #Signs ... #Symptoms
Short Stature - Differential Diagnosis Algorithm
Normal Variant, Normal Puberty Onset (BA = CA)
 • Familial Short
Short Stature - Differential ... Deprivation • Primary ... • Cushing's Disease ... Panhypopituitarism Treatment ... Chemotherapy • Bone
Paget’s Disease: Pathogenesis and Clinical Findings

 • Incr serum CTx - marker of bone resorption
 •
Paget’s Disease: ... CTx - marker of bone ... resorption • Lytic bone ... ALP - marker of bone ... #symptoms
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
neurodegenerative disease ... Signs and symptoms ... • Primary Progressive ... Multiple Sclerosis Treatment ... management #neurology #treatment
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
• Ligament • Bone ... or nerve root Symptoms ... the subchondral bone ... #Joint #Pain #MSK ... approach #workup #differential
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: ... cause excessive bone ... turnover -> Incr bone ... formation MSK ... #diagnosis #signs