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hematology hemeonc hemophagocytic hlh lymphohistiocytosis apml chronic cll dermatology differentiation emergencies leukemia leukostasis lymphocytic lysis oncologic serotonin sweet tls toxicology
Management of Serotonin Syndrome Identify and stop all serotoninergic medications • Avoid inadvertent Rx of serotoninergic meds
serotoninergic meds ... normalize vital signs ... then 2 mg q2h if symptoms ... continue UCSD ... #Management #treatment
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... WBC >100k, + lab signs ... : - If febrile ... #TLS #diagnosis ... #management #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... full infectious work-up ... - If febrile > ... days → add fungal work-up ... #HemeOnc #Diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Rare: DAH, acute febrile ... : >3 symptoms, or ... #management #hematology ... #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... : HLH signs and ... symptoms can mimic ... acute or subacute febrile ... #management #treatment
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Acute febrile ... Episcleritis Signs ... and Symptoms: ... Treatment: - Systemic ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... microglobulin Treatment ... • Richter’s Syndrome ... #workup #oncology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... consideration in febrile ... hyperinflammatory syndrome ... Presentation • Common Signs ... and Symptoms:
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