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rheumatology sle erythematosus systemic differential druginduced management signs antiphospholipid autoantibodies causes comparison dermatology dil emergencies hemeonc hypercoagulable mimickers oncologic oncology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... Neurological 12% - Thrombocytopenia ... Anti-cardiolipin (aPL ... - Anti-B2GP1 (aPL ... autoantibodies #signs #symptoms
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Algorithm Pinpoint ... hemostasis: - Thrombocytopenia ... Autoimmune Vasculitis (lupus ... : - ITP - APLS ... deficiency Work
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Photosensitivity, Butterfly rash ... Leucopenia/lymphopenia, Thrombocytopenia ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... NPSLE rare, Malar rash ... • Immunologic Workup ... constitutional symptoms ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Malignancy (e.g. hematologic ... vein thrombosis Hematologic ... : • Symptoms limited ... Erythematosus #Diagnosis
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Hypercoagulable Workup ... Algorithm INDICATIONS ... excluded Testing: • Lupus ... #Algorithm #diagnosis ... #hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Constitutional symptoms ... NPSLE rare, Malar rash ... • Immunologic Workup ... #DIL #rheumatology ... #diagnosis #treatment
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... syndrome): - Hematologic ... - CRS: fever, rash ... AML (~20 %) and APL ... Oncology #HemeOnc #Diagnosis
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