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differential rheumatology erythematosus sle systemic causes oncology signs antiphospholipid autoantibodies chronic cll dermatology evaluation hypercoagulable leukemia lymphocytic management mds mimickers
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
Algorithm for workup ... hemolytic uremic syndrome ... , Hematology 2012 ... , p 193 #Diagnosis ... #Differential #Algorithm
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential Diagnosis ... SLE • CLL • APLA ... Non-lmmune: • HELLP Syndrome ... #Hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Neurological 12% - Thrombocytopenia ... Anti-cardiolipin (aPL ... - Anti-B2GP1 (aPL ... autoantibodies #signs #symptoms ... #differential #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Demyelinating syndromes ... Leucopenia/lymphopenia, Thrombocytopenia ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Algorithm Pinpoint ... hemostasis: - Thrombocytopenia ... Autoimmune Vasculitis (lupus ... Rash: - ITP - APLS ... deficiency Work
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Antiribosomal P, APLA ... disorders • CAD APLA ... : • Symptoms limited ... Erythematosus #Diagnosis
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid Syndrome ... (APLS) Testing ... excluded Testing: • Lupus ... #Algorithm #diagnosis ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Neutropenia, anemia, thrombocytopenia ... • Richter’s Syndrome ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... platelet count (thrombocytopenia ... Workup: • Complete ... #diagnosis #hematology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
including systemic lupus ... and the systemic symptoms ... Histopathological Diagnoses ... agonists #TAFRO #diagnosis ... #management #rheumatology
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