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hematology oncology reactions product syndrome transfusion activation adultonset algorithm anemia antinxp2 antinxp2dm aplastic apml cancer causes classification coagulation comparison dermatomyositis
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
arthritis, Skin rash ... Differential Diaqnoses ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
of high parity blood ... : 33% • Treatment ... , and CXR with pulmonary ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... opacities • Diagnosis ... Renal Failure Treatment ... #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Petechial or purpuric rash ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... + Bleeding Treatment ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... screen - determines blood ... maculopapular rash ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... the banked donor blood ... maculopapular rash ... #Transfusion #diagnosis ... #management #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
aplastic anemia Treatment ... result from low blood ... Anemia #oncology #hematology ... #diagnosis #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Workup: • Full Blood ... marrow biopsy - if blood ... Hodgkin Lymphoma Treatment ... classification #hematology ... #oncology #management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... • Erythematous rash ... positive patients Treatment ... #management #rheumatology ... #dermatology
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