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Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Enzymes (LFTs) - Causes ... Cholestatic Liver Injury ... value = (ALT + ULN ... phosphatase + ULN ... #Cholestatic #Transaminitis
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Value = (ALT / ULN ... ALT) / (ALP / ULN ... Hepatocellular injury ... 2: Cholestatic injury ... LFTs #Elevation #Transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Algorithm for Transaminitis ... Severe - ALT >15X ULN ... Moderate - ALT 5-15X ULN ... Mild - ALT < 5x ULN ... Elevated #Abnormal #Transaminitis
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminases / Transaminitis ... images/10587 #Transaminitis ... Differential #Diagnosis #causes
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... Patterns #Liver #Injury ... hepatology #LFTs #transaminitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Drug-induced liver injury ... Diagnosis #hepatology #transaminitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... ALF): • Liver injury ... hepatocellular injury ... differential #Hepatology #transaminitis
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Drugs and Classes ... Type of Liver Injury ... #Pharmacology #Causes
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 Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver Injury ... Framework: Liver Injury ... Hepatocellular Liver Injury ... Hepatocellular #Liver #Injury ... hepatology #algorithm #Transaminitis
Acute Kidney Injury Framework - Differential Diagnosis Algorithm #AKI #Acute #Kidney #Injury #Differential #Diagnosis #Algorithm #causes
Acute Kidney Injury ... Acute #Kidney #Injury ... Diagnosis #Algorithm #causes
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