3178 results
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
involving both UMN ... combination of UMN ... sclerosis with pure UMN ... combination of UMN ... neurology #diagnosis #management
Incomplete spinal cord syndromes (ISCS)
 • Central - Small Lesion - Suspended sensory deficit, classic cape
Disproportionate motor (UMN ... Ipsilateral weakness (UMN ... small band of LMN ... paraparesis (mixed UMN ... and LMN types)
Bilateral LMN palsy with tongue weakness, wasting and fasciculations.  →  Bulbar motor Neuron disease

Note
Bilateral LMN palsy ... differentiates this from an UMN ... fasciculations #LMN
Upper Motor Neuron (UMN) lesions are lesions occurring anywhere in the CNS from the brain up
Motor Neuron (UMN ... However, in UMN ... UMC & LMN lesions ... UMN lesions are ... @DharSaty #UMN
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... Value = (ALT / ULN ... ALT) / (ALP / ULN ... SinaiBmoreIMRes #Liver
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... Hepatocellular Liver ... value = (ALT + ULN ... phosphatase + ULN
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... AST/ALT (5-10x ULN ... Intrahepatic Cholestasis Management ... obgyn #diagnosis #management
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Severe ALT > 15x ULN ... Moderate ALT 5-15x ULN ... Mild ALT < 5x ULN
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Infection • Neuro: UMN ... stroke, tumor), LMN
Spontaneous Bacterial Peritonitis (SBP) - Diagnosis and Management
Ascites PMN > 250/mm3
? Nosocomial or hospital acquired. Recent
Diagnosis and Management ... Ascites PMN > ... SBP: Medical Management ... response - ↓ PMN ... dysfunction or liver