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diagnosis management erythematosus lupus systemic oncology behcets cerebritis chronic classification cll cns cryoglobulinemia cryoglobulins dermatology disease hemophagocytic hlh leukemia lymphocytic
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary ... Anti-UI-ribonucleoprotein ... severe disease Treatment ... #Summary #diagnosis ... #rheumatology #
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
and Management Summary ... Positive in 60-80% of cases ... life-threatening • Treatment ... Diagnosis #Management #Summary ... #rheumatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... and Management Summary ... old, ~10,000 new cases ... only curative treatment ... #hematology #oncology
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Behcet's Syndrome ... - Treatment Ulcers ... : • Treatment: ... Behcets #disease #Syndrome ... #pharmacology #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... autoantibodies that will cause ... Erythematosus #SLE ... CNS #neurology #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia Summary ... • They can cause ... Cryoglobulins Cause ... erythematosus (SLE ... classification #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Autoimmune diseases: SLE ... Drugs, Unknown cause ... Treatment: • ... diagnosis #management #treatment ... #summary #rheumatology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO Syndrome Summary ... SAPHO syndrome is ... Rule out other causes ... and lower jaw Treatment ... #Rheumatology #
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... non-Hodgkin lymphoma SLL ... microglobulin Treatment ... • Richter’s Syndrome ... workup #oncology #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment ... #Rheumatology #
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