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pathophysiology rheumatology sle differential disease erythematosus management manifestations systemic vasculitis arthritis behcet bulimianervosa caudaequina chronic classification cll features gastrointestinal hematology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... > Mouth, Nasal Ulcers ... pathophysiology #diagnosis ... #signs #symptoms ... #complications
Kawasaki Disease (Mucocutaneous Lymph Node Syndrome) An rare systemic acute febrile vasculitic syndrome. Aetiology unknown. Affects
Kawasaki Disease (Mucocutaneous ... Lymph Node Syndrome ... lethal cardiac complications ... Disease #Features #Signs ... #Symptoms #Diagnosis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... - Budd Chiari Syndrome ... Gastrointestinal #Complications ... pathophysiology #signs ... #symptoms #diagnosis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Erythematosus #SLE #MSK ... Musculoskeletal #Complications ... pathophysiology #signs ... #symptoms #diagnosis
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Cauda Equina Syndrome ... / Symptoms / Complications ... #MSK #pathophysiology ... #diagnosis #symptoms ... #signs
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
pain • Extra-CNS complications ... disorders (Systemic lupus ... Manifestations #diagnosis ... #neurology #symptoms ... #signs
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
meningitis), MCC CNS symptoms ... recurrent oral ulcers ... ) Differential Diagnosis ... glucocorticoids • Recurrent mucocutaneous ... #signs #symptoms
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... plaques, nodules, ulcers ... phenomenon CLL Diagnosis ... • Richter’s Syndrome
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Kawasaki Disease: - Mucocutaneous ... genital aphthous ulcers ... such as systemic lupus ... Presentation - Systemic Symptoms ... purpura: strong sign
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... at the time of diagnosis ... skin (16-32%): lupus ... anterior/posterior MSK ... #Management #Signs
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