26 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
(SLE): Musculoskeletal ... #MSK #Musculoskeletal ... Complications #pathophysiology ... #signs #symptoms ... #diagnosis
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
autoimmune disease ... distal to elbows/wrists ... skin thickening Signs ... and Symptoms: ... #diagnosis #signs
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
Pathogenesis and Joint diseases ... boggy" joints, esp carpal ... Boutonniere's ulnar ... #signs #symptoms ... #diagnosis
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... pain (20%) Renal disease ... Thrombocytopenia #Lupus #SLE ... #signs #symptoms ... #diagnosis #rheumatology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
erythematosus (SLE ... ) Signs / Symptoms ... Sjogrens #Syndrome #Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... with no early symptoms ... Physical Exam/Signs ... cells can indicate disease ... workup #oncology #hematology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Lupusreference #SLE ... #Systemic #Lupus ... autoantibodies #signs ... #symptoms #mimickers
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Differential Diagnosis ... pain • Swan neck/Ulnar ... Induced Lupus: • Symptoms ... Erythematosus #Diagnosis
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... Constitutional symptoms ... months to years) Systemic ... Evolution: Chronic disease ... #diagnosis #management
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
- Differential Diagnosis ... Infection - Systemic ... arthritis - SLE ... #differential #diagnosis ... #msk #physicalexam