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diagnosis acute aids aki associated causes dementia differential disorder emergencies hand hematology hemeonc hiv injury kidney leukostasis lysis management neurocognitive
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... (TLS) Tumor Cell ... / Xanthine -> Uric ... Precipitation => • Urate ... #TLS #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... : • Pathophysiology ... phos, Elevated uric ... , Elevated Cr, Low ... #TLS #diagnosis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Kidney Injury - AKI Workup ... Algorithm and Differential ... electrolytes, urea ... , uric acid, osmolarity ... #Diagnosis #nephrology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... antibiotics TLS ... acid, high LDH, low ... Ca - q8 h TLS ... high d-dimer, low
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
HIV dementia Pathophysiology ... ARVs can have low ... volume • Patchy areas ... The clinical syndrome ... Treatment: • HAART
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