12 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... thiazide-sensitive sodium-chloride ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Workup Algorithm ... electrolytes, urea ... investigations depending on clinical ... #Workup #Algorithm ... Differential #Diagnosis #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... thiazide-sensitive sodium ... tubule (DCT) Clinical ... #nephrology #management ... #pathophysiology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Pathophysiology: ... Diagnosis (Clinical ... • Associated with ... • Urine sodium ... #Hepatology #Nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Urinary Chloride Algorithm ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... the excretion of sodium ... #nephrology #differential
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework

Heat Cramps:
 • Muscle pain or spasm -
Dehydration - Loss of sodium ... on the skin • Areas ... Rhabdomyolysis - AKI ... Syncope / Exercise Associated ... Collapse: • Pathophysiology
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
men • Commonly associated ... Pathophysiology ... : • Associated ... Clinical Manifestations ... others (botox, sodium
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV dementia Pathophysiology ... volume • Patchy areas ... Clinical Presentation ... : The clinical ... syndrome of HAD
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Dermatomyositis Clinical ... declines > ALT) • AKI ... + myoglobin AKI ... Heme associated ... causes #treatment #nephrology
Principal patterns of loss of sensation.
 (a) Thalamic lesion: sensory loss throughout opposite side (rare).
syrinx: 'suspended' areas ... 'dissociated', ... Brown—Séquard syndrome ... Comprehensive Review in Clinical ... Neurology - https