19 results
Nephron - Diuretic Sites of Action

Source Text: https://www.sciencedirect.com/book/9780323449427/critical-care-nephrology#book-info

#Nephron #Diuretics #Site #Action #Location #Nephrology #Pathophysiology #Pharmacology
Nephron - Diuretic ... #book-info #Nephron ... #Diuretics #Site ... #Pathophysiology ... #Pharmacology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... Adenosine #Nephron ... #Pathophysiology ... #Action #nephrology ... #pharmacology
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
loop of Henle Gitelman ... Fanconi #Bartter #Gitelman ... #Localization #Nephron ... #Defects #Pathophysiology ... #Nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... delivery to distal nephron ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Differential Diagnosis Algorithm ... Low Cl intake, Diuretics ... High Urine Cl-: Diuretics ... , Gitelman Syndrome ... #nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Differential Diagnosis Algorithm ... Loop and thiazide diuretics ... , Gitelman syndrom ... Differential #Diagnosis #Algorithm ... potassium #low #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Differential Diagnosis Algorithm ... Low Cl intake, Diuretics ... High Urine Cl-: Diuretics ... , Gitelman Syndrome ... #Nephrology #Causes
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... loss through the nephron ... Isosorbide, Mannitol, Urea ... #Pharmacology # ... nephrology #conversion
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
Mechanisms of nephron ... in cardiorenal syndrome ... activities • Diuretic ... #Mechanisms #pathophysiology ... #nephrology
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Differential Diagnosis Algorithm ... >20 mEq/24 h - Diuretics ... , Gitelman's syndrome ... Differential #Diagnosis #Algorithm ... #nephrology #causes