9 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... -> Uric Acid (low ... excretion) • Phosphorus ... Precipitation => • Urate
Hypophosphatemia Diagnostic Algorithm
- GI Losses
- Redistribution
- 1° HPT
- 1° Renal PO4 wasting: Hereditary, TIO, Fanconi Syndrome,
, TIO, Fanconi Syndrome ... Hypophosphatemia #phosphorus ... #low #diagnosis ... #Algorithm #differential ... #nephrology
Hypophosphatemia - Differential Diagnosis Algorithm
Appropriately Low Kidney Phosphate Excretion:
 • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Differential Diagnosis Algorithm ... Appropriately Low ... Tumor Genesis Syndrome ... Differential #Diagnosis #Algorithm ... #nephrology #phosphorus
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Algorithm Cl- ... alkalosis • Normal/low ... , Gitelman syndrome ... #urine #Algorithm ... #nephrology #differential
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Differential Diagnosis Algorithm ... Decreased Intake: • Low ... • Fatigue Chloride ... #Pathophysiology ... #Nephrology #Chloride
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... can be high or low ... Cirrhosis, Nephrotic syndrome ... differential #diagnosis #table ... #sodium #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
thiazide-sensitive sodium chloride ... alkalosis • Normal or low ... • Congenital chloride ... #diagnosis #nephrology ... #management #pathophysiology
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV dementia Pathophysiology ... ARVs can have low ... volume • Patchy areas ... The clinical syndrome ... untreated HIV and with low
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm
Transcellular Shift - Appropriate renal excretion (GFR,
Differential Diagnosis Algorithm ... , TTKG, distal flow ... Osmoles, Increased Urate ... Tumor Lysis Syndrome ... IntercellularShift #Nephrology