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diagnosis differential management treatment causes hypokalemia hyponatremia kidney low neurology siadh acute aids aki alkalosis chloride dementia disorder epithelial glomerular
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... thiazide-sensitive sodium-chloride ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
Inherited Defects ... ascending limb Gitelman ... Increased open time and ... of epithelial sodium ... #Kidney #Nephrology
Causes of Hypomagnesemia - Differential Diagnosis Algorithm GI LOSS - FeMg < 2-2.5% or 24h Urine Mg
2-2.5% or 24h Urine ... 2-2.5% or 24h Urine ... nephrocalcinosis (FHHNC) • Gitelman's ... syndrome • Thiazide ... ab • Genetics defects
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
Urinary Chloride Algorithm ... , Gitelman syndrome ... sodium is typically ... the excretion of sodium ... #Algorithm #nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... thiazide-sensitive sodium ... Hypocalciuria (spot urine ... #nephrology #management ... #pathophysiology
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation Algorithm ... as arrhythmias and ... A urine K/Cr ratio ... , Gitelman syndrome ... differential #potassium #nephrology
Management of SIADH Treat underlying cause: • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
volume overload Urea ... promoting passive sodium ... Saline: • If Urine ... Has many side effects ... #hyponatremia #nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Injury - AKI Workup Algorithm ... electrolytes, urea ... • Cardio-renal syndrome ... #AKI #Workup #Algorithm ... Differential #Diagnosis #nephrology
SIADH Treatment Options 1. Treat underlying cause of SIADH: Pain, Primary lung pathology, Post-operative phenomenon, Medications, Basically
Urea powder • Induces ... promoting passive sodium ... 0.9% NS • If Urine ... • Major side effects ... #hyponatremia #nephrology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... Pathophysiology: ... • Associated with ... • Urine sodium ... #Hepatology #Nephrology
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