17 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... -> Uric Acid (low ... urinary excretion ... Precipitation => • Urate
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Differential Diagnosis Algorithm ... Urine Cl-: Vomiting ... (late) • High Urine ... Differential #Diagnosis #Algorithm ... #nephrology
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... and concentrated urine ... Fatty - Nephrotic syndrome ... #Microscopy #Diagnosis ... #Nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Differential Diagnosis Algorithm ... Urine Cl-: Vomiting ... (late) • High Urine ... #Nephrology #Causes
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Injury - AKI Workup Algorithm ... microscopy / urinary ... calcium Optional: urinary ... electrolytes, urea ... Differential #Diagnosis #nephrology
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
clots ➔ Lower Urinary ... pain hematuria syndrome ... hematuria: - RBC casts ... Upper and Lower urinary ... causes #urology #nephrology
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
Hypothyroidism, Low ... Glucocorticoid deficiency, Primary ... Cirrhosis, Nephrotic syndrome ... #Hyponatremia #algorithm ... #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Differential Diagnosis Algorithm ... • Fanconi's syndrome ... sediment - WBC/RBC casts ... polyangiitis (GPA) / microscopic ... #Proteinuria #Nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation Algorithm ... A urine K/Cr ratio ... • Diarrhea A urine ... differential #potassium #nephrology ... #low
Simplified Approach to Acute Kidney Injury (AKI)
1) IS THIS AN EMERGENCY? 
Is there a dialysis indication
require urgent nephrology ... : Hypovolemia, Low ... circulating volume, Urinary ... IMPROVEMENT If the urine ... Assess UA w/ microscopy