52 results
Uric Acid Homeostasis
In the liver, purines are metabolized to uric acid. The last step in purine
animals, the enzyme uricase ... Uricase is not present ... The gout drug pegloticase ... #Homeostasis #Gout ... #Pathophysiology
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Crystalline - Gout ... arthritis - (Reiter’s syndrome ... Amy Chung, MD, MSc ... Joint #Disorders #msk
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Anterior Cord Syndrome ... • Central Cord Syndrome ... Posterior Cord Syndrome ... #diagnosis #pathophysiology ... signs #symptoms #msk
Patellofemoral Syndrome - Pathogenesis and clinical findings
 • Anterior Knee Pain with possible symptoms of 'catching'
Patellofemoral Syndrome ... Patellofemoral #Syndrome ... #pathophysiology ... signs #symptoms #msk
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
Monoarticular • Gout ... -4 joints) • Gout ... Sicca) Syndrome ... Inflammatory #JointPain #MSK
Carpal Tunnel Syndrome: Pathogenesis and clinical findings
 • Dysthesias - Tingling, burning, or painful sensation at
Carpal Tunnel Syndrome ... #CarpalTunnel #Syndrome ... #pathophysiology ... #msk #overuse
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Effusions: - Gout ... - Pseudo gout ... Osteoarthritis - Overuse syndrome ... Seronegative Reactive Syndrome ... differential #diagnosis #msk
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
- Inherited Urea ... of ammonia: - Urease ... rare): - Reye syndrome ... deficiency #Ammonia #Pathophysiology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... Precipitation => • Urate ... #TumorLysis #Syndrome ... #TLS #Pathophysiology
Primary Bone Tumors - Differential Diagnosis Algorithm 

Metastatic - Most common tumour in adults
 - Breast
in adults - Breast ... Tumors #Tumours #MSK ... Orthopedics #Causes #Oncology