8 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... Lysis Syndrome (TLS ... ) Tumor Cell Lysis ... Precipitation => • Urate ... Hypocalcemia • Hyperkalemia
Hyperkalemia after Missed Hemodialysis - Initial electrocardiogram showed peaked T waves and a prolonged QT segment
Hyperkalemia after ... Hemodialysis - Initial electrocardiogram ... A) #Clinical #Cardiology ... #EM #EKG #Hyperkalemia ... #PeakedT #NEJM
Hypercalcemia of Malignancy - Pathophysiology
PTH-mediated
 • Parathyroid cancer
 • Ectopic production: Small cell lung cancer, ovarian
Hypercalcemia of ... Malignancy - Pathophysiology ... , Breast Cancer, ... @kdjhaveri #Hypercalcemia ... #Malignancy #Pathophysiology
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
of neoplastic cells ... hyperuricemia, #hyperkalemia ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... leukapheresis - TLS ... Lysis of tumor cells ... hydration - Hyperkalemia ... Lysis #Syndrome #TLS
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Pharmacology and Pathophysiology ... pumped outside the cell ... - Hyperkalemia ( ... from entering the cell ... #cardiology
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS ... low Ca - q8 h TLS ... interventional radiology ... “big & sticky” cells ... plasmapheresis Hypercalcemia
Squamous-Cell Carcinoma of the Lung- ...Physical examination revealed decreased air entry in the base of the
Squamous-Cell Carcinoma ... that were in his breast ... #NEJM #clinical ... #radiology #CT # ... squamous #cell #