10 results
Role of Uric Acid in the Inflammation of Gout

Allopurinol, Febuxostat - Xanthine oxidase
Colchicine - Release of
Role of Uric Acid ... Inflammation of Gout ... inflammation #gout ... #uricacid #pathophysiology ... #pharmacology #
Uric Acid Homeostasis
In the liver, purines are metabolized to uric acid. The last step in purine
Uric Acid Homeostasis ... The gout drug pegloticase ... #UricAcid #Homeostasis ... #Gout #Pathophysiology ... #Pharmacology #
Hyperuricemia - Differential Diagnosis Algorithm
Primary - Over-production
     • Increased turnover of nucleotides
Primary
• Lower uric ... Hyperparathyroidism • Diabetic ... • Alcohol #gout ... #UricAcid #Hyperuricemia
TACROLIMUS - Side Effects Mnemonic

Tremor 
Alopecia 
Cardiovascular (HTN) 
Renal insufficiency 
Oncologic (Skin Cancer) 
Lipids (hyperlipidemia) 
Insulin
Insulin dependent diabetes ... Magnesium wasting Uric ... Seizures #Pharmacology
Causes of Hyperuricemia
Increased production
 • Solid-organ transplant
 • Tumor lysis syndrome
 • Rhabdomyolysis
 • Lesch Nyhan
lactic acid + uric ... degradation -> uric ... -> purines -> uric ... Hyperuricemia #Causes #UricAcid ... #differential #gout
Oral Hypoglycemics in Diabetes Management
1  INSULIN SENSITIZER
 • TZD 
     -
Hypoglycemics in Diabetes ... Amaryl), Glyburide (Diabeta ... degradation, slows gut ... Hypoglycemics #Diabetes ... #Management #pharmacology
Serum Uric Acid Levels - Primary vs Secondary Gout .Often the serum urate level is higher
Serum Uric Acid ... Primary vs Secondary Gout ... higher than primary gout ... #Diagnosis #UricAcid ... Primary #Secondary #Gout
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... mechanisms within the gut ... #Metformin #Pharmacology ... #Summary #DM2 #diabetes
Allopurinol Pharmacology Summary

Xanthine oxidase inhibitor blocking the formation of new uric acid
Initiate 1-2 days prior to
Allopurinol Pharmacology ... formation of new uric ... #Allopurinol #Pharmacology ... pathophysiology #gout ... #uricacid
GLP-1 Receptor Agonists - Pharmacology Summary
Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
Receptor Agonists - Pharmacology ... produced by the gut ... Receptor #Agonists #Pharmacology ... #Summary #DM2 #diabetes