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diagnosis differential management rheumatology algorithm hlh intravascular lymphohistiocytosis workup anemia cell coagulation cryofibrinogenemia dermatology dili disseminated druginduced extravascular hemolysis hemolytic
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Myelogenous Leukemia • Primary ... effect following treatment ... Diagnosis #Algorithm #Causes ... #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
/Quantity: • Primary ... marrow disease - DIC ... Coagulation Defects: • DIC ... Purpura Fulminans (DIC ... Differential #Diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
+ Bleeding Treatment ... : • Treat primary ... cause • Correct ... #treatment #management ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Hemophagocytic Lymphohistiocytosis ... (HLH) Treatment ... Primary HLH: - ... EricsMedicalLectures/ #HLH #Hemophagocytic ... #management #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation (DIC ... usually IgM) (e.g. primary ... Extravascular #Causes ... differential #diagnosis #hematology
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
almost) all TMAs cause ... There are primary ... Primary TMA is due ... children, so I did ... Microangiopathy #TMAs #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... assessment+++ Primary ... Drugs, Unknown cause ... Treatment: • ... #summary #rheumatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... biliary obstruction, Primary ... biliary cholangitis, Primary ... Diagnosis #Algorithm #hepatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Better call hematology ... EPO-independent (primary ... up EPO levels Primary ... always a good idea ... Algorithm #workup #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Primary (essential ... cryoglobulins • Negative causes ... skin necrosis • DIC ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
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