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diagnosis differential glomerular neurology proteinuria pulmonary renal syndrome basement comparison cord diseases disorders glomerulonephritis goodpastures hematuria management membrane membranoproliferative microscopy
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... Diagnosis: • Anti-GBM ... weeks By Tess Litchman ... #Goodpastures #AntiGBM ... #diagnosis #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... Differential Diagnosis Algorithm ... proliferative • Anti-GBM ... Minimal change disease ... #Proteinuria #Nephrology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
sclerosis • Anti-Glomerular ... testing: anti-ANCA ... ab, anti-GBM ab ... biopsy By Tess Litchman ... differential #diagnosis #nephrology
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... Differential Diagnosis Algorithm ... disease • ... wall) • Anti-GBM ... • Pauci-immune disease
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
Immunofluorescence Microscopy (IM ... Electron Microscopy (EM ... Amyloid RPGN • Anti-GBM ... polyangiitis #glomerular ... #diseases #nephrology
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... Cytomegalovirus; GBM ... impairment), heart disease ... Nephrocalcinosis causes ... nephrotic #syndrome #nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
dysmorphic RBC, RBC casts ... (Dense deposit disease ... immune deposits on EM ... microangiopathy (TMA), anti-phospholipid ... Glomerulonephritis #MPGN #nephrology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
mimicry or super-antigen ... levels • NMO-IgG (anti-AQP4 ... • Infectious causes ... Brucellosis - Dengue, EBV ... AntiCRMP IgG, Anti-Hu
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Non-compressive Spinal Cord Causes ... Mycoplasma, Influenza, EBV ... Hemorrhage - Ant ... Sarcoidosis, Behcet disease ... differential #algorithm
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