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differential algorithm acute diseases injury kidney management rheumatology ana anca antineutrophil antinuclear classification comparison glomerular kidneyinjury myelitis neurology pathology proteinuria
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... Vasculitis: • Microscopic ... ANCA+ 90% • Anti-GBM ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Kidney Injury (AKI ... - Differential Diagnosis ... Vasculitis • GN: ANCA, Anti-GBM ... Medicine @SCVMCMed #AKI ... #nephrology #causes
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... Glomerulonephritis • Anti-GBM ... antibodies • ... polyangiitis /microscopic ... #KidneyInjury #Nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
EGPA) • Renal: (AKI ... EGPA) • Auto-antibodies ... Anti-GBM antibody ... usually low in anti-GBM ... Goodpasture's cause
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... dipstick, urine microscopy ... osmolarity If cause ... Vasculits: ANCA, ANA, Anti-GBM ... #nephrology #causes
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... glomerular #diseases #nephrology ... comparison #table #diagnosis
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... proliferative • Anti-GBM ... antibodies ... polyangiitis (GPA) / microscopic ... #Proteinuria #Nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
-ANCA): • Microscopic ... tract, and often causes ... glomerulonephritis) • Anti-GBM ... Dx: GPA, EGPA, microscopic ... C-ANCA) pattern: antibodies
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
levels • NMO-IgG (anti-AQP4 ... • Infectious causes ... glycoprotein (MOG) antibody ... AntiCRMP IgG, Anti-Hu ... Antiamphiphysin antibodies
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