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differential acute aki rheumatology glomerulonephritis injury kidney pulmonary renal vasculitis ana antibody antineutrophil antinuclear classification diseases hematuria kidneyinjury management progressive
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... Vasculitis: • Microscopic ... + 90% • Anti-GBM ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Glomerulonephritis - Differential Diagnosis Framework ANCA: • C-ANCA: GPA (Wegener's) • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
- Differential Diagnosis ... : Microscopic Polyangiitis ... Churg Strauss) Anti-GBM ... #differential #diagnosis ... #nephrology #causes
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Henoch-SchonIein Purpura Anti-GBM ... antibodies (linear ... Limited to Kidney: Anti-GBM ... pulmonary involvement: Anti-GBM
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... Disease-specific testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP ... #nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... dipstick, urine microscopy ... , ANA, Anti-GBM, ... Anti-ds-DNA, C3 ... #nephrology #causes
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
proliferative • Anti-GBM ... antibodies ... polyangiitis (GPA) / microscopic ... #Proteinuria #Nephrology ... #Algorithm #Causes
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... Algorithm Red ... wall) • Anti-GBM ... antibodies ... #Algorithm #Causes
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
- Differential Diagnosis ... Vasculitis • GN: ANCA ... , Anti-GBM, C3/C4 ... #nephrology #causes ... #algorithm
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Glomerulonephritis • Anti-GBM ... antibodies • ... polyangiitis /microscopic ... #KidneyInjury #Nephrology ... #Algorithm #Causes
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
): • Microscopic ... tract, and often causes ... glomerulonephritis) • Anti-GBM ... Dx: GPA, EGPA, microscopic ... ) pattern: antibodies
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