17 results
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Differential Diagnosis ... polyangiitis, Microscopic ... ab, anti-GBM ab ... #differential #diagnosis ... #nephrology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
disease c-ANCA - Vasculitis ... granulomatosis p-ANCA - Vasculitis ... Microscopic polyangiitis ... Celiac disease Anti-GBM ... Associations #diseases #diagnosis
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... glomerular #diseases #nephrology ... comparison #table #diagnosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANCA-Associated Vasculitis ... : • Microscopic ... Renal-limited vasculitis ... ANCA+ 90% • Anti-GBM ... Antineutrophil #antibodies #diagnosis
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
- Differential Diagnosis ... Wegener's) • P-ANCA: Microscopic ... Churg Strauss) Anti-GBM ... #differential #diagnosis ... #nephrology #causes
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated Vasculitis ... polyangiitis (GPA), microscopic ... involvement - PR3>MPO Microscopic ... 90%, rarely PR3 Anti-GBM ... PANCA #MPO #PR3 #Diagnosis
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
- Differential Diagnosis ... Emboli, Thrombosis, Vasculitis ... • GN: ANCA, Anti-GBM ... #Differential #Diagnosis ... #nephrology #causes
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... dipstick, urine microscopy ... Glomerulonephritis / Vasculits ... : ANCA, ANA, Anti-GBM ... #nephrology #causes
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... PR3-ANCA): • Microscopic ... glomerulonephritis) • Anti-GBM ... (anti-C1q Vasculitis ... Dx: GPA, EGPA, microscopic
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... Inflammatory: Vasculitis ... Coxsackie, HIV, CMV, EBV ... #Differential #Diagnosis ... #neurology