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differential causes algorithm aki rheumatology acute kidney neurology pulmonary renal anca antibodies hematuria management table acutekidneyinjury ana antibody antigbm antineutrophil
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Differential Diagnosis ... polyangiitis, Microscopic ... ab, anti-GBM ab ... #differential #diagnosis ... #nephrology
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... #nephrology #pathology ... comparison #table #diagnosis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
c-ANCA - Vasculitis ... granulomatosis p-ANCA - Vasculitis ... Microscopic polyangiitis ... Anti-GBM - Goodpasture's ... #diagnosis #table
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANCA-Associated Vasculitis ... : • Microscopic ... Renal-limited vasculitis ... ANCA+ 90% • Anti-GBM ... Antineutrophil #antibodies #diagnosis
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... - Differential Diagnosis ... Emboli, Thrombosis, Vasculitis ... • GN: ANCA, Anti-GBM ... #nephrology #causes
Acute Kidney Injury (AKI) - Differential Diagnosis Framework PRE-Renal AKI: • Hypovolemia • Congestion • Medications •
Acute Kidney Injury ... - Differential Diagnosis ... Immune-complex disease ... , Anti-GBM • Tubular ... #nephrology
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
- Differential Diagnosis ... cells on urine microscopy ... disease • ... wall) • Anti-GBM ... • Pauci-immune disease
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... dipstick, urine microscopy ... Glomerulonephritis / Vasculits ... : ANCA, ANA, Anti-GBM ... #nephrology #causes
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
polyangiitis (GPA), microscopic ... involvement - PR3>MPO Microscopic ... 90%, rarely PR3 Anti-GBM ... disease - MPO>PR3 ... PANCA #MPO #PR3 #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... PR3-ANCA): • Microscopic ... glomerulonephritis) • Anti-GBM ... (anti-C1q Vasculitis ... Dx: GPA, EGPA, microscopic
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