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diagnosis differential pulmonary management renal rheumatology table algorithm ana anca antigbm antineutrophil antinuclear associations autoantibodies basement causes comparison disease giomeruiar
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Microscopic polyangiitis ... U1-RNP antibody ... Endomyseal antibody ... Anti-GBM - Goodpasture's ... #rheumatology #antibodies
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear Antibody ... Antineutrophil cytoplasmic antibodies ... Vasculitis: • Microscopic ... ANCA+ 90% • Anti-GBM ... Antineutrophil #antibodies
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... (IM) - Electron ... Microscopy (EM) ... Amyloid RPGN • Anti-GBM ... #nephrology #pathology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... testing: anti-ANCA ... ab, anti-GBM ab ... biopsy By Tess Litchman ... differential #diagnosis #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
proliferative • Anti-GBM ... antibodies ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... EGPA) • Auto-antibodies ... : ANCA antibody, ... Anti-GBM antibody ... usually low in anti-GBM
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... (Goodpasture's Disease ... Diagnosis: • Anti-GBM ... weeks By Tess Litchman ... AntiGBM #diagnosis #nephrology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
levels • NMO-IgG (anti-AQP4 ... sclerosis, NMOSD, MOG antibody ... glycoprotein (MOG) antibody ... AntiCRMP IgG, Anti-Hu ... Antiamphiphysin antibodies
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