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diagnosis differential rheumatology renal algorithm anca antibodies causes management neurology syndromes table ana antibody antigbm antineutrophil antinuclear associated associations autoantibodies
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Peripheral edema, Disease-specific ... , Behcet disease ... Goodpasture's Disease ... dysmorphic RBCs) • Disease-specific ... ab, anti-GBM ab
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... Microscopy (EM) ... Minimal change disease ... Amyloid RPGN • Anti-GBM ... #glomerular #diseases
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... - Graves' disease ... (TTG) - Celiac disease ... Anti-GBM - Goodpasture's ... #Associations #diseases
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... : • Microscopic ... ANCA+ 90% • Anti-GBM ... disease - MPO>PR3 ... #rheumatology #diseases
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal ... - Anti-GBM Disease ... Positive (ANCA + anti-GBM ... , Behcet's Disease ... , mitral valve disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
glomerulonephritis) • Anti-GBM ... (anti-C1q Vasculitis ... disease, and ocular ... (Granulomatous disease ... atherosclerotic disease
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... With associated pulmonary ... involvement: Anti-GBM ... Disease (Goodpasture's
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... life-threatening diseases ... Inflammatory eye disease ... ANCA antibody, Anti-GBM ... usually low in anti-GBM
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated Vasculitis ... polyangiitis (GPA), microscopic ... involvement - PR3>MPO Microscopic ... 90%, rarely PR3 Anti-GBM ... disease - MPO>PR3
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Systemic rheumatic diseases ... atherosclerotic disease ... most important diseases ... (GRANULOMATOUS DISEASE ... abdominal pain and GN Anti-GBM
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