12 results
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... vasculitis, Behcet disease ... sclerosis • Anti-Glomerular ... Goodpasture's Disease ... ab, anti-GBM ab
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
diseases Light ... Microscopy (EM) ... Minimal change disease ... Amyloid RPGN • Anti-GBM ... #diseases #nephrology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease)

What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... Disease (Goodpasture's ... Disease) What ... Diagnosis: • Anti-GBM ... #Membrane #Disease
Causes of acute kidney injury (AKI). AKI is classified into pre-renal, renal, and post-renal causes. Renal
vascular supply; glomerular ... and interstitial disease ... GBM, Glomerular ... basement membrane ... Causes #Sites #Nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
• Vascular • Glomerular ... Immune-complex disease ... , Anti-GBM • Tubular ... Bilateral ureteral disease ... Differential #Diagnosis #nephrology
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
with evidence of glomerular ... disease (hematuria ... post-infectious GN Anti-Glomerular ... Basement Membrane ... Differential #Diagnosis #Nephrology
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
urine sediment Microscopic ... Thin basement membrane ... disease - Alport ... disease Renal ... causes #urology #nephrology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
membrane: Goodpasture ... life-threatening diseases ... Inflammatory eye disease ... ANCA antibody, Anti-GBM ... usually low in anti-GBM
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Drugs Glomerular ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
(Dense deposit disease ... immune deposits on EM ... microangiopathy (TMA), anti-phospholipid ... Glomerulonephritis #MPGN #nephrology ... #diagnosis #renal