13 results
diagnosis differential vasculitis algorithm antibodies glomerulonephritis pulmonary renal workup acute aki antibody antineutrophil antinuclear associated associations autoantibodies autoimmune canca classification
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Vasculitis: • Microscopic ... + 90% • Anti-GBM ... antibodies #diagnosis #rheumatology ... #diseases
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
ANA - Non-specific ... c-ANCA - Vasculitis ... granulomatosis p-ANCA ... Microscopic polyangiitis ... Anti-GBM - Goodpasture's
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis) - ANCA-negative ... testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated ... 90%, rarely PR3 Anti-GBM ... disease - MPO>PR3 ... @AnnKumfer #ANCA ... #Diagnosis #Rheumatology
Glomerulonephritis - Differential Diagnosis Framework ANCA: • C-ANCA: GPA (Wegener's) • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Diagnosis Framework ANCA ... : • C-ANCA: GPA ... Wegener's) • P-ANCA ... Churg Strauss) Anti-GBM ... #causes
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... pulmonary involvement: Anti-GBM ... (C-ANCA): GPA > ... (P-ANCA): eGPA,
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
dipstick, urine microscopy ... Glomerulonephritis / Vasculits: ANCA ... , ANA, Anti-GBM, ... Anti-ds-DNA, C3 ... Differential #Diagnosis #nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
): • Microscopic ... often causes arthritis ... glomerulonephritis) • Anti-GBM ... Dx: GPA, EGPA, microscopic ... differential #diagnosis #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
PT, aPTT(liver disease ... function test, ANA ... ), HBsAg/anti-HBc ... When do you do a BM ... #Workup #hematology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... Auto-antibodies: ANCA ... antibody, Anti-GBM ... usually low in anti-GBM ... Goodpasture's cause
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