14 results
diagnosis differential algorithm management pulmonary vasculitis neurology renal treatment anca antibody antigbm antineutrophil antinuclear associations autoantibodies autoimmune basement classification disease
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antineutrophil cytoplasmic antibodies ... Vasculitis: • Microscopic ... + 90% • Anti-GBM ... #diagnosis #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
ANA - Non-specific ... Microscopic polyangiitis ... Anti-GBM - Goodpasture's ... diagnosis #table #rheumatology ... #antibodies
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Henoch-SchonIein Purpura Anti-GBM ... antibodies (linear ... Limited to Kidney: Anti-GBM ... pulmonary involvement: Anti-GBM
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... cells on urine microscopy ... disease • ... wall) • Anti-GBM ... antibodies
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
proliferative • Anti-GBM ... antibodies ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP ... differential #diagnosis #nephrology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
PT, aPTT(liver disease ... antibodies, Quantitative ... ), HBsAg/anti-HBc ... When do you do a BM ... #Workup #hematology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... (Goodpasture's Disease ... Diagnosis: • Anti-GBM ... weeks By Tess Litchman ... AntiGBM #diagnosis #nephrology
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
- but 5% have anti—muscle-specific ... More likely to cause ... glucocorticoids - can cause ... Hospital of Baltimore IM ... diagnosis #management #neurology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... EGPA) • Auto-antibodies ... Anti-GBM antibody ... usually low in anti-GBM ... Goodpasture's cause
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