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diagnosis differential vasculitis anca antibodies classification management algorithm antibody antineutrophil antinuclear associated associations autoantibodies autoimmune canca disorders glomerulonephritis hemophagocytic hlh
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
ANA - Non-specific ... (AMA), Anti-sp100 ... Microscopic polyangiitis ... Anti-GBM - Goodpasture's ... diagnosis #table #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Vasculitis: • Microscopic ... + 90% • Anti-GBM ... antibodies #diagnosis #rheumatology ... #diseases
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... pulmonary involvement: Anti-GBM ... diagnosis #algorithm #rheumatology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP ... differential #diagnosis #nephrology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
PT, aPTT(liver disease ... function test, ANA ... ), HBsAg/anti-HBc ... When do you do a BM ... #Workup #hematology
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
polyangiitis (GPA), microscopic ... involvement - PR3>MPO Microscopic ... 90%, rarely PR3 Anti-GBM ... disease - MPO>PR3 ... PR3 #Diagnosis #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... Adult-onset Still disease ... Drugs, Unknown cause ... chemotherapy, anti-CD20 ... treatment #summary #rheumatology
Subglottic stenoses (SGS) during systemic diseases Subglottic stenosis (SGS) = congenital (children) or acquired (adult) characterized by
, anti-BPAg1/BP230 ... • Bronchial fibroscopy ... PET-CT Acquired causes ... differential #diagnosis #causes ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
): • Microscopic ... often causes arthritis ... glomerulonephritis) • Anti-GBM ... LFT • ESR • ANA ... differential #diagnosis #rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
of about three cases ... • History of EBV ... Lymphoma (90-95% of cases ... number of sites of disease ... classification #hematology
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